PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines

@article{Konda2014PEG400AE,
  title={PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines},
  author={Shankaraiah G. Konda},
  journal={European Journal of Chemistry},
  year={2014},
  volume={5},
  pages={676-680}
}
  • S. Konda
  • Published 31 December 2014
  • Chemistry
  • European Journal of Chemistry
An efficient and convenient route is described for the synthesis of new pyrazolo [1,5-a] pyrimidine derivatives by the reaction of 4-(4’-chloro-phenylazo)-5-amino pyrazole with α,β-unsaturated carbonyl compounds (chalcones) using polyethylene glycol (PEG-400) as benign reaction medium. The advantage of this protocol includes the excellent yields, operational simplicity, short reaction times and avoidance of volatile organic solvents and expensive catalysts. 

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