PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis.

  title={PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis.},
  author={Emile J. M. Rijcken and Rudolf B. Mennigen and Sebastian Daniel Sch{\"a}fer and Mike Georg Laukoetter and Christoph Anthoni and H. -U. Spiegel and Matthias Bruewer and Norbert Senninger and C. F. Krieglstein},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={293 2},
Transendothelial migration of circulating leukocytes into the colonic wall is a key step in the development of the inflammatory infiltrate in inflammatory bowel disease (IBD). The platelet-endothelial cell adhesion molecule-1 PECAM-1 (CD31) is expressed in the tight junction area of endothelial cells, where it is supposed to support the transmigration process. The aim of this study was to determine the role of PECAM-1 in experimental IBD and to show whether blockade of PECAM-1 has therapeutic… CONTINUE READING


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