PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes.

  title={PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes.},
  author={C J Treutiger and Andreas Heddini and Victor Fernandez and William A Muller and M Wahlgren},
  journal={Nature medicine},
  volume={3 12},
Excessive binding of Plasmodium falciparum-infected red blood cells (pRBCs) to the vascular endothelium (cytoadherence) and to uninfected erythrocytes (rosetting) may lead to occlusion of the microvasculature and thereby contribute directly to the acute pathology of severe human malaria. A number of endothelial receptors have been identified as targets for the pRBCs, including CD36, intercellular adhesion molecule-1 (ICAM-1) and chondroitin-4-sulfate (CSA). In vitro, CD36 is the most frequent… CONTINUE READING
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