PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.

Abstract

Regulation of the DNA damage response and cell cycle progression is critical for maintaining genome integrity. Here, we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner. PEA15 expression oscillates throughout the cell cycle, and the loss of PEA15 accelerates cell cycle progression by… (More)
DOI: 10.1128/MCB.01542-13

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Cite this paper

@article{Nagarajan2014PEA15RT, title={PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.}, author={Arvindhan Nagarajan and Shaillay Kumar Dogra and Alex Yang Liu and Michael R. Green and Narendra Wajapeyee}, journal={Molecular and cellular biology}, year={2014}, volume={34 12}, pages={2264-82} }