PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.

@article{Chou2003PEA15BT,
  title={PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.},
  author={Fan-Li Chou and Justine M. Hill and Jyh-Cheng Hsieh and Jacques M. Pouyssegur and Anne Sophie Brunet and Angela Glading and Florian Uberall and Joe W Ramos and Milton H. Werner and Mark H Ginsberg},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={52587-97}
}
Activation of Raf-1 suppresses integrin activation, potentially through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). However, bulk ERK1/2 activation does not correlate with suppression. PEA-15 reverses suppression of integrin activation and binds ERK1/2. Here we report that PEA-15 reversal of integrin suppression depends on its… CONTINUE READING