PDZRN3 Negatively Regulates BMP-2–induced Osteoblast Differentiation through Inhibition of Wnt Signaling

@inproceedings{Honda2010PDZRN3NR,
  title={PDZRN3 Negatively Regulates BMP-2–induced Osteoblast Differentiation through Inhibition of Wnt Signaling},
  author={T. Honda and Hisato Yamamoto and Aiko Ishii and Makoto Inui},
  booktitle={Molecular biology of the cell},
  year={2010}
}
PDZRN3 is a member of the PDZ domain-containing RING finger family of proteins. We previously showed that PDZRN3 is essential for the differentiation of C2C12 mouse mesenchymal progenitor cells into myotubes. Mesenchymal progenitor cells differentiate into osteoblasts, chondrocytes, and adipocytes in addition to myotubes, and we have now examined the potential role of PDZRN3 in the differentiation of C2C12 cells into osteoblasts. The abundance of PDZRN3 in C2C12 cells was increased after the… CONTINUE READING
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