PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.

@article{Yesilaltay2006PDZK1IR,
  title={PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.},
  author={Ayce Yesilaltay and Olivier Kocher and Rinku Pal and Andrea Leiva and Ver{\'o}nica Qui{\~n}ones and Attilio A Rigotti and Monty Krieger},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 39},
  pages={28975-80}
}
PDZK1 is a multi-PDZ domain-containing adaptor protein that binds to the C terminus of the high density lipoprotein receptor, scavenger receptor, class B, type I (SR-BI), and controls the posttranscriptional, tissue-specific expression of this lipoprotein receptor. In the absence of PDZK1 (PDZK1(-/-) mice), murine hepatic SR-BI protein levels are very low (<5% of control). As a consequence, abnormal plasma lipoprotein metabolism ( approximately 1.5-1.7-fold increased total plasma cholesterol… CONTINUE READING