PDZ domains - common players in the cell signaling.

  title={PDZ domains - common players in the cell signaling.},
  author={F. Jelen and Arkadiusz Oleksy and Katarzyna Śmietana and Jacek Otlewski},
  journal={Acta biochimica Polonica},
  volume={50 4},
PDZ domains are ubiquitous protein interaction modules that play a key role in cellular signaling. Their binding specificity involves recognition of the carboxyl-terminus of various proteins, often belonging to receptor and ion channel families. PDZ domains also mediate more complicated molecular networks through PDZ-PDZ interactions, recognition of internal protein sequences or phosphatidylinositol moieties. The domains often form a tandem of multiple copies, but equally often such tandems or… CONTINUE READING
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