PDZ-domain-binding sites are common among cadherins

  title={PDZ-domain-binding sites are common among cadherins},
  author={Fabio Demontis and Bianca H Habermann and Christian Dahmann},
  journal={Development Genes and Evolution},
Cadherins are Ca2+-dependent cell adhesion molecules that play fundamental roles in animal development and homeostasis. A number of cadherins contain conserved binding sites for catenins in their cytoplasmic region that are important for the adhesive function of these cadherins by mediating their interaction to the cytoskeleton. However, most cadherins lack apparent binding sites for catenins and their cytoplasmic interacting partners are mostly unknown. In this paper, we show, using… CONTINUE READING

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