PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer.

@article{Park2006PDZbindingKC,
  title={PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer.},
  author={Jae-Hyun Park and Meng-Lay Lin and Toshihiko Nishidate and Yusuke Nakamura and Toyomasa Katagiri},
  journal={Cancer research},
  year={2006},
  volume={66 18},
  pages={9186-95}
}
Breast cancer is one of the most common cancers among women. To discover molecular targets that are applicable for development of novel breast cancer therapy, we previously did genome-wide expression profile analysis of 81 breast cancers and found dozens of genes that were highly and commonly up-regulated in breast cancer cells. Among them, we here focused on one gene that encodes PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), including a kinase domain. Northern blot… CONTINUE READING

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