PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.

@article{Mikelis2013PDZRhoGEFAL,
  title={PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.},
  author={Constantinos M. Mikelis and Todd R Palmby and May Simaan and Wenling Li and Roman Szabo and Ruth Lyons and Daniel Mart{\'i}n and Hiroshi Yagi and Shigetomo Fukuhara and Hiroki Chikumi and Rebeca Galisteo and Yoh-Suke Mukouyama and Thomas H Bugge and J. Silvio Gutkind},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 17},
  pages={12232-43}
}
G protein-coupled receptors (GPCRs) linked to both members of the Gα12 family of heterotrimeric G proteins α subunits, Gα12 and Gα13, regulate the activation of Rho GTPases, thereby contributing to many key biological processes. Multiple Rho GEFs have been proposed to link Gα12/13 GPCRs to Rho activation, including PDZ-RhoGEF (PRG), leukemia-associated Rho GEF (LARG), p115-RhoGEF (p115), lymphoid blast crisis (Lbc), and Dbl. PRG, LARG, and p115 share the presence of a regulator of G protein… CONTINUE READING
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Semaphorin 4 D signaling requires the recruitment of phospholipase C  into the plexinB 1 receptor complex

  • I. Oinuma, H. Katoh, A. Harada, M. Negishi
  • Mol . Cell . Biol .
  • 2009

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