PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses

@article{Daw2000PDZPI,
  title={PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses},
  author={Michael I Daw and Ramesh Chittajallu and Zuner Assis Bortolotto and Kumlesh K Dev and Fabrice Duprat and Jeremy M Henley and Graham L Collingridge and John T R Isaac},
  journal={Neuron},
  year={2000},
  volume={28},
  pages={873-886}
}
We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide ("pep2-SVKI") into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. Pep2-SVKI, but not a control or PICK1 selective peptide, caused AMPAR-mediated EPSC amplitude to increase in approximately one-third of control neurons and in most neurons following the prior induction of LTD. Pep2-SVKI also blocked LTD; however, this occurred in all… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 76 references

A role for protein

Z. A. Bortolotto, G. L. Collingridge
2000
View 6 Excerpts
Highly Influenced

Role of AMPA receptor cycling area CA 1 of the rat hippocampus

C. Lüscher, H. Xia, +4 authors R. A. Nicoll
Eur . J . Neurosci . • 1999
View 5 Excerpts
Highly Influenced

AMPA receptors in hippocampal neurons is regulated by an NSF

Lee, H.-K, K. Kameyama, R. L. Huganir, M. F. Bear
1998
View 14 Excerpts
Highly Influenced

of AMPA receptors in hippocampal

K. Kameyama, R. L. Huganir, M. F. Bear
NEURONS • 1998
View 12 Excerpts
Highly Influenced

A synaptic model

T.V.P. Bliss, G. L. Collingridge
1993
View 4 Excerpts
Highly Influenced

Surface expression

J. Noel, G. S. Ralph, +5 authors J. M. Henley
1999
View 5 Excerpts
Highly Influenced

Long - term depression in the 2262 – 2267 . hippocampus

G. O. Hjelmstad, R. A. Nicoll, R. C. Malenka
Annu . Rev . Neurosci . • 1997
View 5 Excerpts
Highly Influenced

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