PDR3, a new yeast regulatory gene, is homologous toPDR1 and controls the multidrug resistance phenomenon

@article{Delaveau1994PDR3AN,
  title={PDR3, a new yeast regulatory gene, is homologous toPDR1 and controls the multidrug resistance phenomenon},
  author={Thierry Delaveau and Agn{\'e}s Delahodde and Elvira Carvajal and J{\'u}lius {\vS}ub{\'i}k and Claude Jacq},
  journal={Molecular and General Genetics MGG},
  year={1994},
  volume={244},
  pages={501-511}
}
TheSaccharomyces cerevisiae PDR3 gene, located near the centromere of chromosome II, has been completely sequenced and characterised. Mutationspdr3-1 andpdr3-2, which confer resistance to several antibiotics can be complemented by a wild-type allele of the PDR3 gene. The sequence of the wild-typePDR3 gene revealed the presence of a long open reading frame capable of encoding a 976-amino acid protein. The protein contains a single Zn(II)2Cys6 binuclear-type zinc finger homologous to the DNA… CONTINUE READING
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