PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.

@article{Dong2005PDK2TM,
  title={PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.},
  author={Lily Q. Dong and Feng Liu},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={289 2},
  pages={E187-96}
}
Activation of members of the protein kinase AGC (cAMP dependent, cGMP dependent, and protein kinase C) family is regulated primarily by phosphorylation at two sites: a conserved threonine residue in the activation loop and a serine/threonine residue in a hydrophobic motif (HM) near the COOH terminus. Although phosphorylation of these kinases in the activation loop has been found to be mediated by phosphoinositide-dependent protein kinase-1 (PDK1), the kinase(s) that catalyzes AGC kinase… CONTINUE READING
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