PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.

@article{Inagaki1999PDK1HA,
  title={PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.},
  author={Masaaki Inagaki and Tobias Schmelzle and Kumiko Yamaguchi and Kenji Irie and Michael N. Hall and Kunihiro Matsumoto},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 12},
  pages={8344-52}
}
PDK1 (phosphoinositide-dependent kinase 1) is a mammalian growth factor-regulated serine/threonine kinase. Using a genetic selection based on a mutant form of the yeast MAP kinase kinase Ste7, we isolated a gene, PKH2, encoding a structurally and functionally conserved yeast homolog of PDK1. Yeast cells lacking both PKH2 and PKH1, encoding another PDK1 homolog, were nonviable, indicating that Pkh1 and Pkh2 share an essential function. A temperature-sensitive mutant, pkh1(D398G) pkh2, was… CONTINUE READING
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