PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

@article{Scott2002PDK1dependentAO,
  title={PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.},
  author={Mary T Scott and Angela Ingram and Kathryn L. Ball},
  journal={The EMBO journal},
  year={2002},
  volume={21 24},
  pages={
          6771-80
        }
}
p21(WAF1/CIP1) Contributes to positive and negative growth control on multiple levels. We previously mapped phosphorylation sites within the C-terminal domain of p21 that regulate proliferating cell nuclear antigen binding. In the current study, a kinase has been fractionated from mammalian cells that stoichiometrically phosphorylates p21 at the Ser146 site, and the enzyme has been identified as an insulin-responsive atypical protein kinase C (aPKC). Expression of PKCzeta or activation of the… CONTINUE READING
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