PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.

@article{Belgardt2008PDK1DI,
  title={PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.},
  author={Bengt F. Belgardt and Andreas Husch and Eva Rother and Marianne B Ernst and F Thomas Wunderlich and Brigitte Hampel and Tim Kl{\"o}ckener and Dario Alessi and Peter Kloppenburg and Jens C. Br{\"u}ning},
  journal={Cell metabolism},
  year={2008},
  volume={7 4},
  pages={291-301}
}
Insulin- and leptin-stimulated phosphatidylinositol-3 kinase (PI3K) activation has been demonstrated to play a critical role in central control of energy homeostasis. To delineate the importance of pathways downstream of PI3K specifically in pro-opiomelanocortin (POMC) cell regulation, we have generated mice with selective inactivation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in POMC-expressing cells (PDK1(DeltaPOMC) mice). PDK1(DeltaPOMC) mice initially display hyperphagia… CONTINUE READING
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