PDK1 coordinates survival pathways and β-adrenergic response in the heart

  title={PDK1 coordinates survival pathways and β-adrenergic response in the heart},
  author={K. Ito and H. Akazawa and M. Tamagawa and K. Furukawa and W. Ogawa and N. Yasuda and Y. Kudo and C.-h. Liao and R. Yamamoto and T. Sat{\^o} and J. D. Molkentin and M. Kasuga and T. Noda and H. Nakaya and I. Komuro},
  journal={Proceedings of the National Academy of Sciences},
  pages={8689 - 8694}
  • K. Ito, H. Akazawa, +12 authors I. Komuro
  • Published 2009
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • The 3-phosphoinositide-dependent kinase-1 (PDK1) plays an important role in the regulation of cellular responses in multiple organs by mediating the phosphoinositide 3-kinase (PI3-K) signaling pathway through activating AGC kinases. Here we defined the role of PDK1 in controlling cardiac homeostasis. Cardiac expression of PDK1 was significantly decreased in murine models of heart failure. Tamoxifen-inducible and heart-specific disruption of Pdk1 in adult mice caused severe and lethal heart… CONTINUE READING
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