PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis

@inproceedings{Zhang2015PDIA3KE,
  title={PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis},
  author={Xue-qun Zhang and Yue Pan and Chao-hui Yu and Cheng-fu Xu and Lei Xu and You-ming Li and Wei-xing Chen and Anna Alisi},
  booktitle={PloS one},
  year={2015}
}
Nonalcoholic fatty liver disease (NAFLD) has emerged as one of the most common chronic liver disease over the past decades. Endoplasmic reticulum stress (ERS) plays a pivotal role during the development of NAFLD. This study aims to analyze the potential role of protein disulfide isomerase A3 precursor (PDIA3), one of the ER chaperones, in free fatty acid-induced cell model of NAFLD. Human liver L02 cell line was treated with sodium palmitate for 24 hours, which developed severe intracellular… CONTINUE READING

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