PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.

@article{Dunford2011PDHAD,
  title={PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.},
  author={Emily C E Dunford and Eric A. F. Herbst and Nam Ho Jeoung and William B. Gittings and J Greig Inglis and Rene Vandenboom and Paul J LeBlanc and Robert A. Harris and Sandra J. Peters},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={300 6},
  pages={R1487-93}
}
Pyruvate dehydrogenase (PDH) plays an important role in regulating carbohydrate oxidation in skeletal muscle. PDH is deactivated by a set of PDH kinases (PDK1, PDK2, PDK3, PDK4), with PDK2 and PDK4 being the most predominant isoforms in skeletal muscle. Although PDK2 is the most abundant isoform, few studies have examined its physiological role. The role of PDK2 on PDH activation (PDHa) at rest and during muscle stimulation at 10 and 40 Hz (eliciting low- and moderate-intensity muscle… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…