PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.

@article{Zhang2007PDGFRsAC,
  title={PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.},
  author={Hongbing Zhang and Natalia Bajraszewski and Erxi Wu and Hongwei Wang and Annie P. Moseman and Sandra L. Dabora and James D. Griffin and David J Kwiatkowski},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 3},
  pages={
          730-8
        }
}
The receptor tyrosine kinase/PI3K/Akt/mammalian target of rapamycin (RTK/PI3K/Akt/mTOR) pathway is frequently altered in tumors. Inactivating mutations of either the TSC1 or the TSC2 tumor-suppressor genes cause tuberous sclerosis complex (TSC), a benign tumor syndrome in which there is both hyperactivation of mTOR and inhibition of RTK/PI3K/Akt signaling, partially due to reduced PDGFR expression. We report here that activation of PI3K or Akt, or deletion of phosphatase and tensin homolog… CONTINUE READING

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