PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.

  title={PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.},
  author={Tatsuya Ozawa and C. V. Weiss Brennan and Lu Wang and Massimo Squatrito and Takashi Sasayama and M. Nakada and Jason T Huse and A. J. Donaire Pedraza and Satoshi Utsuki and Yoshie Yasui and Adesh Tandon and Elena I. Fomchenko and Hidehiro Oka and Ross L. Levine and Kiyotaka Fujii and Marc Ladanyi and Eric C. Holland},
  journal={Genes & development},
  volume={24 19},
Gene rearrangement in the form of an intragenic deletion is the primary mechanism of oncogenic mutation of the epidermal growth factor receptor (EGFR) gene in gliomas. However, the incidence of platelet-derived growth factor receptor-α (PDGFRA) gene rearrangement in these tumors is unknown. We investigated the PDGFRA locus in PDGFRA-amplified gliomas and identified two rearrangements, including the first case of a gene fusion between kinase insert domain receptor (KDR) (VEGFRII) and the PDGFRA… CONTINUE READING


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The impact of translocations and gene fusions on cancer causation

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