PDGFRα signalling promotes fibrogenic responses in collagen‐producing cells in Duchenne muscular dystrophy

@inproceedings{Ieronimakis2016PDGFRS,
  title={
PDGFRα signalling promotes fibrogenic responses in collagen‐producing cells in Duchenne muscular dystrophy},
  author={Nicholas Ieronimakis and Aislinn L Hays and Amalthiya Prasad and Kajohnkiart Janebodin and Jeremy S. Duffield and M. Florencia Reyes},
  booktitle={The Journal of pathology},
  year={2016}
}
Fibrosis is a characteristic of Duchenne muscular dystrophy (DMD), yet the cellular and molecular mechanisms responsible for DMD fibrosis are poorly understood. Utilizing the Collagen1a1-GFP transgene to identify cells producing Collagen-I matrix in wild-type mice exposed to toxic injury or those mutated at the dystrophin gene locus (mdx) as a model of DMD, we studied mechanisms of skeletal muscle injury/repair and fibrosis. PDGFRα is restricted to Sca1+, CD45- mesenchymal progenitors. Fate… CONTINUE READING
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