PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized alpha 2-macroglobulin.

@article{Bonner1990PDGFstimulatedFP,
  title={PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized alpha 2-macroglobulin.},
  author={James C. Bonner and A A Badgett and A R Osornio-Vargas and M. Hoffman and Arnold R. Brody},
  journal={Journal of cellular physiology},
  year={1990},
  volume={145 1},
  pages={1-8}
}
alpha-Macroglobulins derived from plasma or secreted by macrophages are platelet-derived growth factor (PDGF) binding proteins that compete with cell-surface receptors on fibroblasts for PDGF binding. alpha 2-Macroglobulin (alpha 2M) derived from bovine plasma was tested for its ability to modulate the PDGF-induced proliferation of primary passage rat lung fibroblasts (RLFs) and a human skin fibroblast cell line (CRL 1508). Fibroblasts were grown in 10% fetal bovine serum (FBS) for 24 hr, then… CONTINUE READING
Highly Cited
This paper has 183 citations. REVIEW CITATIONS

Citations

Publications citing this paper.

183 Citations

0100200'92'97'03'09'15
Citations per Year
Semantic Scholar estimates that this publication has 183 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…