PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts.

@article{Kim2010PDGFSI,
  title={PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts.},
  author={Jieun E. Kim and Qiong Wu and Yolanda Zhang and Katie M. Wiens and Ying Huang and Nicole Rubin and Hiroyuki Shimada and Robert I. Handin and Michael Y. Chao and T Tuan and Vaughn A. Starnes and Ching-ling Lien},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 40},
  pages={17206-10}
}
A zebrafish heart can fully regenerate after amputation of up to 20% of its ventricle. During this process, newly formed coronary blood vessels revascularize the regenerating tissue. The formation of coronary blood vessels during zebrafish heart regeneration likely recapitulates embryonic coronary vessel development, which involves the activation and proliferation of the epicardium, followed by an epithelial-to-mesenchymal transition. The molecular and cellular mechanisms underlying these… CONTINUE READING