PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading

@article{Roberts2001PDGFregulatedRR,
  title={PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading},
  author={Marnie S Roberts and Simon Barry and Alison J Woods and Peter van der Sluijs and Jim C Norman},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={1392-1402}
}
Background: It has been postulated that the regulation of integrin vesicular Addresses: *Department of Biochemistry, University of Leicester, University Road, traffic facilitates cell migration by internalizing integrins at the rear of the cell Leicester, LE1 7EH, United Kingdom. †Systems and transporting them forward within vesicles for exocytosis at the leading Research, GlaxoSmithKline, Medicines edge to form new contacts with the extracellular matrix. The rab family of Research Centre… CONTINUE READING
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Cytohesin - 1 regulates  2 integrin - mediated adhesion through both ARF - GEF function and interaction with LFA - 1

  • C Geiger, W Nagel, T Boehm, Y vanKooyk, CG Figdor, E Kremmer
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