PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.

Abstract

Chronic liver damage may lead to liver fibrosis. In this process, hepatic activated stellate cells are the key players. Thus, activated stellate cells are attractive targets for antifibrotic gene therapy. Recombinant adenovirus is a promising vehicle for delivering therapeutic genes to liver cells. However, this vector has considerable tropism for… (More)
DOI: 10.1021/mp700118p

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Cite this paper

@article{Schoemaker2008PDGFreceptorBA, title={PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.}, author={Marieke H Schoemaker and Marianne G. Rots and Leonie Beljaars and Arjen Y Ypma and Peter Jansen and Klaas Poelstra and Han J. Moshage and Hidde J. Haisma}, journal={Molecular pharmaceutics}, year={2008}, volume={5 3}, pages={399-406} }