PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition

@article{Balciunaite2000PDGFIT,
  title={PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition},
  author={Egle Balciunaite and Steven J. M. Jones and A. C. Toker and Andrius Kazlauskas},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={261-267}
}
BACKGROUND Platelet-derived growth factor (PDGF) promotes cell-cycle progression by engaging signaling enzymes such as phospholipase Cgamma (PLCgamma). When activated, PLCgamma cleaves phosphatidylinositol-4,5-bisphosphate to produce inositol-1,4, 5-trisphosphate (IP(3)) and diacylglycerol (DAG). IP(3) stimulates the release of calcium from intracellular stores, which together with DAG activate some protein kinase C (PKC) family members. In this study we focused on putative downstream effectors… CONTINUE READING

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