PDGF- and TGF-beta-induced changes in cell shape of invertebrate immunocytes: effect of calcium entry blockers.

@article{Ottaviani1997PDGFAT,
  title={PDGF- and TGF-beta-induced changes in cell shape of invertebrate immunocytes: effect of calcium entry blockers.},
  author={Enzo Ottaviani and Davide Sassi and Dimitris Kletsas},
  journal={European journal of cell biology},
  year={1997},
  volume={74 4},
  pages={336-41}
}
The cellular activity of hemocytes from the marine mollusc Mytilus galloprovincialis was studied using computer-assisted microscopic image analysis. PDGF-AB and TGF-beta 1 caused changes in cellular shape and induced the immunocytes to migrate in a chemotactic manner. The effect of PDGF-AB was more potent than that of TGF-beta 1, and the responses were dose-correlated for PDGF-AB, while they were dose-dependent up to 5 pg/ml for TGF-beta 1. Moreover, the PDGF-AB response was extracellular Ca(2… CONTINUE READING

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