PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse.

@article{Brown1994PDGFAT,
  title={PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse.},
  author={Rebeccah L. Brown and M P Breeden and David G. Greenhalgh},
  journal={The Journal of surgical research},
  year={1994},
  volume={56 6},
  pages={562-70}
}
Impaired wound healing results in significant morbidity for the surgical patient. The genetically diabetic (C57BL/KsJ-db/db) mouse is obese, hyperglycemic, insulin-resistant, and exhibits markedly impaired wound healing. Previous studies have demonstrated that the fibroblast mitogens, BB homodimer of platelet-derived growth factor (PDGF-BB) or basic fibroblast growth factor, plus insulin-like growth factor, act synergistically to enhance wound closure in the genetically diabetic mouse. The… CONTINUE READING