PDGF-D, a new protease-activated growth factor

  title={PDGF-D, a new protease-activated growth factor},
  author={William J. Larochelle and Michael E. Jeffers and William F. McDonald and Rajeev A. Chillakuru and Neill A. Giese and Nathalie A. Lokker and Carol Sullivan and Ferenc L. Boldog and Meijia Yang and Corine Vernet and Catherine E. Burgess and Elma R. Fernandes and Lisa L. Deegler and Beth Rittman and Juliette Shimkets and Richard A. Shimkets and Jonathan M. Rothberg and Henri S. Lichenstein},
  journal={Nature Cell Biology},
Platelet-derived growth factor (PDGF) has been directly implicated in developmental and physiological processes, as well as in human cancer, fibrotic diseases and arteriosclerosis. The PDGF family currently consists of at least three gene products, PDGF-A, PDGF-B and PDGF-C, which selectively signal through two PDGF receptors (PDGFRs) to regulate diverse cellular functions. After two decades of searching, PDGF-A and B were the only ligands identified for PDGFRs. Recently, however, database… CONTINUE READING