PDGF-C is a new protease-activated ligand for the PDGF α-receptor

@article{Li2000PDGFCIA,
  title={PDGF-C is a new protease-activated ligand for the PDGF $\alpha$-receptor},
  author={Xuri Li and Annica Pont{\'e}n and Karin Aase and Linda Karlsson and Alexandra Abramsson and Marko Uutela and Gudrun Bäckström and Mats Hellstr{\"o}m and Hans Boström and Hong Li and Philippe Soriano and Christer Betsholtz and Carl-Henrik Heldin and Kari Alitalo and Arne {\"O}stman and Ulf Eriksson},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={302-309}
}
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the… 
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A new member of the PDGF family, PDGF D, which also requires proteolytic activation is identified and characterized, which indicates that PDGFR-α activation may result from PDG FR-α/β heterodimerization.
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression.
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TPA (tissue plasminogen activator) and matriptase as major proteases for processing of PDGF-C in MCF7 cells are identified and by site-directed mutagenesis, the cleavage site for these proteases in PD GF-C is identified.
Platelet-Derived Growth Factor
  • J. Bonner
  • Biology, Medicine
    Reference Module in Biomedical Sciences
  • 2021
Expression and function of PDGF-C in development and stem cells
TLDR
The expression and functions of PDGF-C and its receptors in development and stem cells are discussed and their importance will be of great importance to various research disciplines.
Biological activities of novel Platelet-derived growth factors, PDGF-C and PDGF-D
TLDR
It is suggested that PDGF-C andPDGF-D are potent modulators of vascular growth, as well as powerful mitogens for connective tissue cells for therapeutic angiogenesis and to recruit mural cells.
Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF α and β Receptor*
TLDR
A third member of the PDGF family (PDGF-C) is described as a potent mitogen for cells of mesenchymal origin inin vitro and in vivo systems with a binding pattern similar to PDGF-AB.
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TLDR
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