PDGF-C is a new protease-activated ligand for the PDGF α-receptor

  title={PDGF-C is a new protease-activated ligand for the PDGF α-receptor},
  author={Xuri Li and Annica Pont{\'e}n and Karin Aase and Linda Karlsson and Alexandra Abramsson and Marko Uutela and Gudrun B{\"a}ckstr{\"o}m and Mats Hellstr{\"o}m and Hans Bostr{\"o}m and Hong Li and Philippe Soriano and Christer Betsholtz and Carl-Henrik Heldin and Kari Alitalo and Arne {\"O}stman and Ulf Eriksson},
  journal={Nature Cell Biology},
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the… CONTINUE READING


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