PDGF-BB inhibits intervertebral disc cell apoptosis in vitro.


Degeneration of the intervertebral disc (IVD) results in deterioration of the spinal motion segment and can lead to debilitating back pain. Given the established mitotic and anti-apoptotic effects of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in a variety of cell types we postulated that rhPDGF-BB might delay disc cell degeneration… (More)
DOI: 10.1002/jor.22638


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@article{Presciutti2014PDGFBBII, title={PDGF-BB inhibits intervertebral disc cell apoptosis in vitro.}, author={Steven M Presciutti and David N. Paglia and Teja Karukonda and Do Yu Soung and Rosa M. Guzzo and Hicham Drissi and Isaac L. Moss}, journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society}, year={2014}, volume={32 9}, pages={1181-8} }