PDGF-B Gene Therapy Accelerates Bone Engineering and Oral Implant Osseointegration

  title={PDGF-B Gene Therapy Accelerates Bone Engineering and Oral Implant Osseointegration},
  author={Po-Chun Chang and Yang Jo Seol and Joni Augusto Cirelli and Gaia R. Pellegrini and Qiming Jin and Lea M. Franco and Steven A. N. Goldstein and Lois A. Chandler and Barbara A Sosnowski and William V Giannobile},
  booktitle={Gene Therapy},
Platelet-derived growth factor-BB (PDGF-BB) stimulates repair of healing-impaired chronic wounds such as diabetic ulcers and periodontal lesions. However, limitations in predictability of tissue regeneration occur due, in part, to transient growth factor bioavailability in vivo. Here, we report that gene delivery of PDGF-B stimulates repair of oral implant extraction socket defects. Alveolar ridge defects were created in rats and were treated at the time of titanium implant installation with a… CONTINUE READING
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