PDGF-AA, a potent mitogen for cardiac fibroblasts from adult rats.

  title={PDGF-AA, a potent mitogen for cardiac fibroblasts from adult rats.},
  author={Andreas Simm and Matthias Nestler and Viviane Hoppe},
  journal={Journal of molecular and cellular cardiology},
  volume={29 1},
The heart responds to increased haemodynamic load with growth of the ventricles. The rise in ventricle mass is due to increasing mass of the myocytes and proliferation of fibroblasts and smooth muscle cells. The accompanying adaptation and remodelling of the interstitium, e.g. production and composition of the extracellular matrix proteins, determine a physiological or pathophysiological hypertrophy. Fibroblasts play a critical role in this process as the producers of extracellular matrix… CONTINUE READING


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