PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.

@article{Meelkop2012PDFRS,
  title={PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.},
  author={Ellen Meelkop and Liesbet Temmerman and Tom Janssen and Nick Suetens and Isabel Beets and Liesbeth Van Rompay and Nilesh Shanmugam and Steven J. Husson and Liliane Schoofs},
  journal={Molecular and cellular endocrinology},
  year={2012},
  volume={361 1-2},
  pages={232-40}
}
In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF… CONTINUE READING