PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors

@article{Mertens2005PDFRS,
  title={PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors},
  author={Inge Mertens and Anick Vandingenen and Erik C B Johnson and Orie Thomas Shafer and Wenke Li and Jennifer S. Trigg and Arnold de Loof and Liliane Schoofs and Paul H Taghert},
  journal={Neuron},
  year={2005},
  volume={48},
  pages={213-219}
}
The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of Neurofibromatosis Factor 1 significantly… CONTINUE READING
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