PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling.

@article{Wang2008PDE5MO,
  title={PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling.},
  author={Songbo Wang and Gang Ning and Xiufen Chen and Jiange Yang and H. F. Ouyang and Hua Zhang and Ping Tai and Xinyi Mu and Bo Zhou and Meijia Zhang and Guoling Xia},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={7087-95}
}
Phosphodiesterase type 5 (PDE5), a cGMP specific, cGMP binding phosphodiesterase, specifically hydrolyzes cGMP to 5'-GMP. Here, we examine the distribution of PDE5 in mouse ovary and its effects on spontaneous maturation of mouse oocytes. PDE5 is present in oocytes and cumulus cells of big, antral follicles. Inhibition of activity of PDE5 significantly and reversibly inhibits spontaneous maturation of cumulus-oocyte complexes (COCs). Suppressive effect of PDE5 on spontaneous maturation of COCs… CONTINUE READING

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