PDE5 is converted to an activated state upon cGMP binding to the GAF A domain.

@article{Rybalkin2003PDE5IC,
  title={PDE5 is converted to an activated state upon cGMP binding to the GAF A domain.},
  author={Sergei D. Rybalkin and Irina G Rybalkina and Masami Shimizu-Albergine and Xiao-bo Tang and Joseph A. Beavo},
  journal={The EMBO journal},
  year={2003},
  volume={22 3},
  pages={469-78}
}
cGMP-specific, cGMP-binding phosphodiesterase (PDE5) regulates such physiological processes as smooth muscle relaxation and neuronal survival. PDE5 contains two N-terminal domains (GAF A and GAF B), but the functional roles of these domains have not been determined. Here we show that recombinant PDE5 is activated directly upon cGMP binding to the GAF A domain, and this effect does not require PDE5 phosphorylation. PDE5 exhibited time- and concentration-dependent reversible activation in… CONTINUE READING

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