PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway.

@article{Robichaud2001PDE4II,
  title={PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway.},
  author={Annette Robichaud and Chantal Savoie and Panagiota B Stamatiou and Frederick D Tattersall and C C Chan},
  journal={Neuropharmacology},
  year={2001},
  volume={40 2},
  pages={262-9}
}
The objective of this work was to assess the role of alpha(2)-adrenoceptors in emesis induced by inhibitors of type 4 phosphodiesterase (PDE4) in ferrets. Pre-treatment with yohimbine, MK-912 or MK-467 (alpha(2)-adrenoceptor antagonists) caused sudden and unexpected vomiting. In contrast, clonidine (alpha(2)-adrenoceptor agonist) did not induce emesis at… CONTINUE READING