PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

@article{Robichaud2001PDE4II,
  title={PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway},
  author={Annette Robichaud and Chantal Savoie and Panagiota B Stamatiou and F. David Tattersall and C. C. Chan},
  journal={Neuropharmacology},
  year={2001},
  volume={40},
  pages={262-269}
}
The objective of this work was to assess the role of alpha(2)-adrenoceptors in emesis induced by inhibitors of type 4 phosphodiesterase (PDE4) in ferrets. Pre-treatment with yohimbine, MK-912 or MK-467 (alpha(2)-adrenoceptor antagonists) caused sudden and unexpected vomiting. In contrast, clonidine (alpha(2)-adrenoceptor agonist) did not induce emesis at doses ranging from 62.5-250 microg/kg s.c. At the dose of 250 microg/kg, clonidine also provided protection against emesis induced by the PDE4… Expand
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