PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation.

@article{Schmitz2007PDE4IP,
  title={PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation.},
  author={Thomas Schmitz and Evelyne Souil and Roxane Herv{\'e} and Carole Nicco and Fr{\'e}d{\'e}ric Batteux and Guy Germain and Dominique Cabrol and Dani{\`e}le Evain-Brion and M Leroy and C{\'e}line M{\'e}hats},
  journal={Journal of immunology},
  year={2007},
  volume={178 2},
  pages={1115-21}
}
The aim of this study was to explore the anti-inflammatory properties of phosphodiesterase-4 (PDE4) inhibitors in vivo and their potential ability to prevent inflammation-induced preterm delivery. Indeed, intrauterine inflammation is the major etiology of very preterm delivery, the leading cause of neonatal mortality and morbidity. Intrauterine injection of Escherichia coli LPS in 15-day-pregnant mice induced an increase of PDE4 activity and PDE4B expression at the maternofetal interface, a… CONTINUE READING