PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.

@article{Molenaar2013PDE3BN,
  title={PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.},
  author={Peter Molenaar and Torsten Christ and Rizwan I. Hussain and Andreas K. Engel and Emanuel Berk and Katherine T. Gillette and Lu Yun Chen and Alejandro Galindo-Tovar and Kurt Allen Krobert and Ursula Ravens and Finn Olav Levy and Alberto Julio Kaumann},
  journal={British journal of pharmacology},
  year={2013},
  volume={169 3},
  pages={
          528-38
        }
}
BACKGROUND AND PURPOSE PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilostamide (0.3-1 μM) or PDE4 inhibitor rolipram (1-10 μM) modified the positive inotropic and lusitropic effects of catecholamines in human failing myocardium. EXPERIMENTAL APPROACH Right and left ventricular trabeculae from freshly explanted hearts of 5 non-β-blocker… CONTINUE READING

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