PDE2 inhibition: potential for the treatment of cognitive disorders.

  title={PDE2 inhibition: potential for the treatment of cognitive disorders.},
  author={Laurent Gomez and James Guy Breitenbucher},
  journal={Bioorganic & medicinal chemistry letters},
  volume={23 24},
Phosphodiesterase inhibition has received much attention in the past 20 years for the potential treatment of CNS disorders. A primary focus of this work is the enhancement of memory and/or cognitive functioning. The role of PDEs in the augmentation of cyclic nucleotide signaling makes these enzymes attractive targets for enhancing the effects of neuronal communication. This review focuses on recent findings with respect to the role of PDE2 inhibition in cognitive functioning. Special attention… CONTINUE READING

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