PDE1C negatively regulates growth factor receptor degradation and promotes VSMC proliferation.

Abstract

T he endothelium regulates the contractile status of vascular smooth muscle cells (VSMCs). 1 The interaction between endothelial cells (ECs) and VSMCs plays an important role in regulating vascular homeostasis. ECs release vasoactive factors , such as prostacyclin, (nitric oxide [NO]), and endothe-lium-derived hyperpolarizing factor, which participate in… (More)
DOI: 10.1161/CIRCRESAHA.115.306139

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