PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.

@article{Suzuki2008PDCD4IT,
  title={PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.},
  author={Chikako Suzuki and Robert G. Garces and K. Andrew Edmonds and Sebastian Hiller and Sven G Hyberts and Assen Marintchev and Gerhard Wagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 9},
  pages={3274-9}
}
Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit translation initiation, and act as a tumor suppressor. PDCD4 contains two C-terminal MA3 domains, which are thought to be responsible for its inhibitory function. Here, we analyze the structures and inhibitory functions of these two PDCD4 MA3 domains by x-ray crystallography, NMR, and surface plasmon resonance. We show that both MA3 domains are structurally and functionally very similar… CONTINUE READING
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