PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.

  title={PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.},
  author={Nora M Barboza and Svetlana Minakhina and Daniel J. Medina and Binaifer Balsara and Sonya Greenwood and Lien Huzzy and Arnold B. Rabson and R. Steward and Dale G Schaar},
  journal={Cancer biology & therapy},
  volume={14 6},
PDCD2 is an evolutionarily conserved eukaryotic protein with unknown function. The Drosophlia PDCD2 ortholog Zfrp8 has an essential function in fly hematopoiesis. Zfrp8 mutants exhibit marked lymph gland hyperplasia that results from increased proliferation of partially differentiated hemocytes, suggesting Zfrp8 may participate in cell growth. Based on the above observations we have focused on the role of PDCD2 in human cancer cell proliferation and hypothesized that aberrant PDCD2 expression… CONTINUE READING
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