PDCD1 single nucleotide genes polymorphisms confer susceptibility to juvenile-onset systemic lupus erythematosus.

@article{Mahmoudi2015PDCD1SN,
  title={PDCD1 single nucleotide genes polymorphisms confer susceptibility to juvenile-onset systemic lupus erythematosus.},
  author={Mahdi Mahmoudi and Alireza Rezaiemanesh and Arash Salmaninejad and Sara Harsini and Shiva Poursani and Tayyeb Bahrami and Fatemeh Tahghighi and Vahid Ziaee and Nima Attaran Rezaei},
  journal={Autoimmunity},
  year={2015},
  volume={48 7},
  pages={488-93}
}
Juvenile-onset systemic lupus erythematosus (JSLE) is a multisystem autoimmune disease in which both the genetic and environmental factors seem to be involved in the etiopathogenesis of the disease. The aim of this study was to evaluate the association of programmed cell death 1 (PDCD1, also called PD-1) gene polymorphisms with JSLE susceptibility in Iranian population. In this case-control association study, three PDCD1 SNPs, including PD-1.1 G/A, PD-1.3 G/A and PD-1.9 C/T were genotyped in 50… CONTINUE READING

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