PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders

@article{James2005PDCD1AT,
  title={PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders},
  author={Ethan S. James and S Harney and Bryan Paul Wordsworth and William O C M Cookson and Seth J Davis and Miriam F Moffatt},
  journal={Genes and Immunity},
  year={2005},
  volume={6},
  pages={430-437}
}
Variation in genes encoding costimulatory molecules expressed on lymphocytes has been expected to contribute to the genetic component of inflammatory disease, but only the gene encoding the inhibitory protein, CTLA-4, seems consistently to confer disease susceptibility. Studies in murine models implicate the inhibitory product of the pd1 gene, programmed death-1, in the maintenance of peripheral tolerance to self-antigens. We identify 22 single-nucleotide polymorphisms (SNPs) in the equivalent… CONTINUE READING
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