PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.

@article{Rapoport2000PD98059PN,
  title={PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.},
  author={Mark Rapoport and Adriana Carolina Marques Ferreira},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 1},
  pages={
          125-33
        }
}
How senile plaques and neurofibrillary tangles are linked represents a major gap in our understanding of the pathophysiology of Alzheimer's disease (AD). We have previously shown that the addition of fibrillar beta-amyloid (Abeta) to mature hippocampal neurons results in progressive neuritic degeneration accompanied by the enhanced phosphorylation of adult tau isoforms. In the present study, we sought to obtain more direct evidence of the signal transduction pathway(s) activated by fibrillar… CONTINUE READING
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